Screening of microorganisms for biodegradation of poly(lactic-acid) and lactic acid-containing polymers

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Screening of microorganisms for biodegradation of poly(lactic-acid) and lactic acid-containing polymers.

The ability of some microorganisms to use lactic acid stereocopolymers and copolymers with glycolic acid as sole carbon and energy sources was studied under controlled or natural conditions. First, 14 filamentous fungal strains were tested in liquid cultures, adopting total lactic acid consumption, nitrogen source exhaustion, and maximal biomass production as selection criteria. Two strains of ...

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Chain Linked Lactic Acid Polymers: Polymerization and Biodegradation Studies

The two-step polymerization method, including polycondensation and chain linking reactions, was conducted to obtain high-molecular-weight lactic acid polymers. The biodegradability of these polymers was subsequently investigated. Three polymerization routes were studied. Hydroxyl-terminated prepolymers were linked with diisocyanates, 1,6-hexamethylene diisocyanate (HMDI) or 1,4-butane diisocyan...

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Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: biodegradation.

A series of previously-synthesized lactic/glycolic acid polymers (PLGA) with various molar ratios of lactic to glycolic acid and various molecular weights were further studied with regard to their biodegradation behavior, and in particular, the factors affecting the biodegradation rate. The biodegradation of PLGA is affected by many factors including polymer composition, molecular weight, and n...

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Biodegradation and Biocompatibility of Poly L-lactic Acid Implantable Mesh

PURPOSE The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. METHODS PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated. RESULTS The weight and tensile strength of the PLLA prosthesis was stab...

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ژورنال

عنوان ژورنال: Applied and Environmental Microbiology

سال: 1996

ISSN: 0099-2240,1098-5336

DOI: 10.1128/aem.62.7.2393-2397.1996